A case-based approach to cancer biology

Cancer is the focus of intense clinical and scientific interest. This research increasingly leverages our understanding of molecular biology for the development of targeted therapeutics. Well-selected case studies provide an opportunity to explain specific examples of cancers and their management in the context of engaging, patient-centered cases. This text is a clinical companion for Weinberg’s The Biology of Cancer. However, it includes sufficient background and explanatory detail to be used on its own.

1. Overview of Cancer and Clinical Oncology
2. Introduction to Cancer Therapy
3. Cytotoxic Chemotherapy
a. Case 3-1: Testicular Cancer
b. Case 3-2: Pancreatic Cancer
4. Protein Kinase Inhibition
a. Case 4-1: Chronic Myelogenous Leukemia
b. Case 4-2: Chronic Lymphocytic Leukemia
c. Case 4-3: Lung Cancer
d. Case 4-4: Metastatic Melanoma
5. Inhibition of the PI3-Kinase/Akt/mTOR Pathway
a. Case 5-1: Renal Cell Carcinoma
b. Case 5-2: Follicular Lymphoma
6. Hormone Therapy
a. Case 6-1: Breast Cancer
b. Case 6-2: Prostate Cancer
7. Differentiation Therapy
a. Case 7-1: Acute Promyelocytic Leukemia
8. Epigenetic Therapy
a. Case 8-1: Myelodysplastic Syndromes
b. Case 8-2: Cutaneous T-cell Lymphoma
9. Targeting Protein Degradation and DNA Repair
a. Case 9-1: Hereditary Breast Cancer
b. Case 9-2: Multiple Myeloma
10. Interference with the Tumor Microenvironment
a. Case 10-1: Colorectal Cancer
b. Case 10-2: Multiple Myeloma
11. Immunological Strategies: Monoclonal Antibodies
a. Case 11-1: Non-Hodgkin Lymphoma
b. Case 11-2: Hodgkin Lymphoma
c. Case 11-3: Breast Cancer
12. Immunological Strategies: Vaccination and
Adoptive T-cell Transfer
a. Case 12-1: Cervical Cancer
b. Case 12-2: Acute Lymphoblastic Leukemia
c. Case 12-3: Metastatic Melanoma

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